Iron Deficiency in Chronic Heart Failure: Diagnostic Algorithm and Present-Day Therapeutic Options (2024)

Doehner, W., Blankenberg, S., Erdmann, E., Ertl, G., Hasenfuß, G., Landmesser, U., Pieske, B., Schieffer, B., Schunkert, H., Von Haehling, S., Zeiher, A., & Anker, S. D. (2017). Iron Deficiency in Chronic Heart Failure: Diagnostic Algorithm and Present-Day Therapeutic Options. Deutsche Medizinische Wochenschrift, 142(10), 752-757. https://doi.org/10.1055/s-0043-100900

Doehner, Wolfram ; Blankenberg, Stefan ; Erdmann, Erland et al. / Iron Deficiency in Chronic Heart Failure : Diagnostic Algorithm and Present-Day Therapeutic Options. In: Deutsche Medizinische Wochenschrift. 2017 ; Vol. 142, No. 10. pp. 752-757.

@article{8b0c8826d646487080036a63976eb587,

title = "Iron Deficiency in Chronic Heart Failure: Diagnostic Algorithm and Present-Day Therapeutic Options",

abstract = "Iron deficiency (ID) occurs in up to 50% of patients with heart failure (HF). Even without presence of anaemia ID contributes to more severe symptoms, increased hospitalization and mortality. A number of randomized controlled trials demonstrated the clinical benefit of replenishment of iron stores with improvement of symptoms and fewer hospitalizations. Assessment of iron status should therefore become routine assessment in newly diagnosed and in symptomatic patients with HF. ID can be identified with simple and straightforward diagnostic steps. Assessment of Ferritin (indicating iron stores) and transferrin saturation (TSAT, indication capability to mobilise internal iron stores) are sufficient to detect ID. In this review a plain diagnostic algorithm for ID is suggested. Confounding factors for diagnosis and adequate treatment of ID in HF are discussed. A regular workup for iron deficiency parameters may benefit patients with heart failure by providing symptomatic improvements and fewer hospitalizations.",

keywords = "anaemia, chronic heart failure, ferritin, iron deficiency, IV iron, TSAT",

author = "Wolfram Doehner and Stefan Blankenberg and Erland Erdmann and Georg Ertl and Gerd Hasenfu{\ss} and Ulf Landmesser and Burkert Pieske and Bernhard Schieffer and Heribert Schunkert and {Von Haehling}, Stephan and Andreas Zeiher and Anker, {Stefan D.}",

note = "Publisher Copyright: {\textcopyright} Georg Thieme Verlag KGStuttgart · New York.",

year = "2017",

month = may,

day = "1",

doi = "10.1055/s-0043-100900",

language = "English",

volume = "142",

pages = "752--757",

journal = "Deutsche Medizinische Wochenschrift",

issn = "0012-0472",

publisher = "Georg Thieme Verlag",

number = "10",

}

Doehner, W, Blankenberg, S, Erdmann, E, Ertl, G, Hasenfuß, G, Landmesser, U, Pieske, B, Schieffer, B, Schunkert, H, Von Haehling, S, Zeiher, A & Anker, SD 2017, 'Iron Deficiency in Chronic Heart Failure: Diagnostic Algorithm and Present-Day Therapeutic Options', Deutsche Medizinische Wochenschrift, vol. 142, no. 10, pp. 752-757. https://doi.org/10.1055/s-0043-100900

Iron Deficiency in Chronic Heart Failure: Diagnostic Algorithm and Present-Day Therapeutic Options. / Doehner, Wolfram; Blankenberg, Stefan; Erdmann, Erland et al.
In: Deutsche Medizinische Wochenschrift, Vol. 142, No. 10, 01.05.2017, p. 752-757.

Research output: Contribution to journal › Review article › peer-review

TY - JOUR

T1 - Iron Deficiency in Chronic Heart Failure

T2 - Diagnostic Algorithm and Present-Day Therapeutic Options

AU - Doehner, Wolfram

AU - Blankenberg, Stefan

AU - Erdmann, Erland

AU - Ertl, Georg

AU - Hasenfuß, Gerd

AU - Landmesser, Ulf

AU - Pieske, Burkert

AU - Schieffer, Bernhard

AU - Schunkert, Heribert

AU - Von Haehling, Stephan

AU - Zeiher, Andreas

AU - Anker, Stefan D.

N1 - Publisher Copyright:© Georg Thieme Verlag KGStuttgart · New York.

PY - 2017/5/1

Y1 - 2017/5/1

N2 - Iron deficiency (ID) occurs in up to 50% of patients with heart failure (HF). Even without presence of anaemia ID contributes to more severe symptoms, increased hospitalization and mortality. A number of randomized controlled trials demonstrated the clinical benefit of replenishment of iron stores with improvement of symptoms and fewer hospitalizations. Assessment of iron status should therefore become routine assessment in newly diagnosed and in symptomatic patients with HF. ID can be identified with simple and straightforward diagnostic steps. Assessment of Ferritin (indicating iron stores) and transferrin saturation (TSAT, indication capability to mobilise internal iron stores) are sufficient to detect ID. In this review a plain diagnostic algorithm for ID is suggested. Confounding factors for diagnosis and adequate treatment of ID in HF are discussed. A regular workup for iron deficiency parameters may benefit patients with heart failure by providing symptomatic improvements and fewer hospitalizations.

AB - Iron deficiency (ID) occurs in up to 50% of patients with heart failure (HF). Even without presence of anaemia ID contributes to more severe symptoms, increased hospitalization and mortality. A number of randomized controlled trials demonstrated the clinical benefit of replenishment of iron stores with improvement of symptoms and fewer hospitalizations. Assessment of iron status should therefore become routine assessment in newly diagnosed and in symptomatic patients with HF. ID can be identified with simple and straightforward diagnostic steps. Assessment of Ferritin (indicating iron stores) and transferrin saturation (TSAT, indication capability to mobilise internal iron stores) are sufficient to detect ID. In this review a plain diagnostic algorithm for ID is suggested. Confounding factors for diagnosis and adequate treatment of ID in HF are discussed. A regular workup for iron deficiency parameters may benefit patients with heart failure by providing symptomatic improvements and fewer hospitalizations.

KW - anaemia

KW - chronic heart failure

KW - ferritin

KW - iron deficiency

KW - IV iron

KW - TSAT

UR - http://www.scopus.com/inward/record.url?scp=85015657982&partnerID=8YFLogxK

U2 - 10.1055/s-0043-100900

DO - 10.1055/s-0043-100900

M3 - Review article

C2 - 28303555

AN - SCOPUS:85015657982

SN - 0012-0472

VL - 142

SP - 752

EP - 757

JO - Deutsche Medizinische Wochenschrift

JF - Deutsche Medizinische Wochenschrift

IS - 10

ER -

Doehner W, Blankenberg S, Erdmann E, Ertl G, Hasenfuß G, Landmesser U et al. Iron Deficiency in Chronic Heart Failure: Diagnostic Algorithm and Present-Day Therapeutic Options. Deutsche Medizinische Wochenschrift. 2017 May 1;142(10):752-757. doi: 10.1055/s-0043-100900